Preheat the grill to medium-high heat,
In a medium bowl add the ground venison, ground pork, Worcestershire sauce, garlic powder, onion powder, red pepper flakes, egg and bread crumbs. Mix together using your hands (using gloves if you prefer – otherwise, make sure to wash hands well before and after handling the meat.
Form patties using ⅔ cup of the meat mixture. First roll each into a nice and tight ball, then flatten each out using your hands.
Lay the venison burger patties out on a baking sheet, season all over with the Creole Seasoning, then take them to the grill.
Lightly spray the grill with cooking spray or oil the grill grates with a little olive oil. When the grill is heated, carefully add the burgers. Allow them to cook for 4-5 minutes, then flip the burgers to cook the other side for another 4-5 minutes.
Double check with a meat thermometer that the internal temperature in the center has reached at least 145°F for medium rare burgers. Add a slice of cheese for the final 1 minute of cooking time.
Melt the butter in a small bowl and brush over the inside of the brioche buns. Place these buns face down on the grill. Cook for about 2 minutes, until crispy and a nice char has formed.
Remove the buns and dress the burgers with toppings of your choice.